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The 3 Best Ways to Integrate CBD for Diabetes from Current Research

By - Milo

Blogger. Researcher. Enthusiast.

Article Take-Aways on Using CBD for Diabetes

If you want the quick summary guideline to maximize your therapeutic use of CBD, you can refer here to what current suggestions say on the matter. If you want to educate yourself further on the subject to help make more informed decisions, read on past the summary!

  1. The quality of fat you consume plays an integral role in your health and living a long healthy life with diabetes, whether it be saturated fats from animals or poly-unsaturated fatty acids from plants, seeds or fish. The role of these fatty acids affected by the compromised insulin signaling within our cells and organs. We can decrease insulin resistance by increasing our consumption of high quality fatty acids such as stearic acid, alpha-lipoid acid and limiting the over consumption of linoleic acid found in highly processed foods (Forouhi et al., 2018).
  2. You current health considerations should determine what you should be focusing on by what your health care practitioner suggests. If you’re overweight, Poly-Unsaturated Fatty Acids (PUFAs) can help reduce cholesterol buildup caused by Low Density Lipids (LDLs) and help lose weight. If you are active and have healthier lifestyle habits, you can increase your insulin sensitivity by reducing your linoleic acid consumption by lowering the amount of PUFAs in your diet by eating nutrient dense (naturally raised) animal organs and bone broths (Telle-Hansen et al., 2019).
  3. CBD can be useful while living with both forms of diabetes as these cannabinoids work within our lipid (fat) metabolite communication system also known as our Endocannabinoid Systems (ECS) by regulating biochemical signals in our bodies and combating the effects of stress and inflammation responses caused by insulin resistance compromised signaling (Horvath et al., 2012)

These three simple considerations have immense implications to your health. Your activity level increases your muscle growth, allowing for more efficient lipid metabolite signaling and decreasing insulin resistance. Your diet, devoid of highly processed foods allows your body to work at it’s most efficient natural state and regulate its internal processes effectively. And CBD has amazing therapeutic potential to combat inflammatory responses caused by the stress occurring from glucose regulation, insulin anemia (the break down of fatty acids into free fatty acids in the blood) which signals to the body to capture this free energy and be stored into visceral fats and the over consumption of linoleic acids from PUFAs that are stored in excess fats (Horvath et al., 2012, Tsalamandris et al., 2019)

We highly recommend you read further as this information, albeit simplified to it’s most basic core values, is imperative for you to understand to live a long healthy life with diabetes or support loved ones who are afflicted with this disease.

DietExerciseControl Inflammatory Responses (Through lifestyle and support from CBD for diabetes)

Introducing the key terms, systems and considerations of our health and CBD for diabetes

It goes without saying, there is a lot of focus on this topic of cannabinoids such as cannabidiol (CBD) and tetrahydrocannabidiol (THC) due to their potential affinity of therapeutic benefits. Our endocannabinoid system (ECS) and associated endocannabinoids a(ECs) are produced at the cellular level and transmit lipid metabolite signals that react between our CB-1 and CB-2 receptors (Horvath et al., 2012). These interactions illicit a number of responses that can play an integral role in metabolic inflammatory diseases such as diabetes. Current research suggests CBD can be very useful in dampening inflammatory responses caused by the pancreas’s limitation of injecting insulin into the bloodstream effectively and the liver’s failure to control blood glucose levels, resulting in stored visceral fat and a plethora of other issues (Tsalamandris et al., 2019)

To read more about the Endocannabinoid System – Click Here

Cannabidiol reacts with our cells through lipid transferred metabolites to illicit a variety of actions in our cells for our therapeutic benefit. These benefits are but aren’t limited to calming effects, pain, sedation, anti-inflammatory and anti-cancerous.

In this article we will outline a few crucial considerations about the effects of diabetes on the body, the natural processes the body fails to regulate due to diabetes and what consideration should be made for those who are looking for life strategies to cope with their affliction. 

What are PUFAs, why is Linoleic Acid a threat and how does this tie together with CBD & Diabetes?


North Americans have seen an increase of dietary linoleic acid in their fat stores by 136% in the past 70 years” – (Guyanet & Carlson et al., 2015)


We will get back to CBD in a bit, but this section here is crucial for everyone to understand. Our relationship with our food and change in diet have increased the amount of inflammatory type auto-immune diseases such as diabetes. 

Dark Leafy Greens are full of acids the plant uses to defend itself from predation, creating digestion issues in our intestines. Raw dark leafy greens are ill-advised produce to consume. Cook to remove harmful phytic and oxalic acids.

Linoleic acid (LA) is a topic that doesn’t reach the headlines often but we need to understand that it is playing an integral role in the demise of our health. Linoleic acid is a fatty acid that is concentrated in nuts, seeds, vegetables and astounding levels are found in processed foods high in poly-unsaturated fatty acids (PUFAs). This particular fatty acid is impacting our health in a variety of ways by potentially increasing visceral fat and hormone disruption which is caused by liver dysfunction in diabetics on a grander scale than those without (Benjamin et al., 2015).

Conjugated Linoleic Acid (CLAs – produced by the fermentation of PUFAs in ruminant animals) is slightly different that LA in terms of one bond that separates the bonds of the molecule, but has implications on the ability to reduce total cholesterol in healthy active adults, may not be advisable to supplement your diet with high saturated fats if you’re already facing obesity (Benjamin et al., 2015).

Think of this, through our evolution as humans, evolutionary biologists have taken note that we increase our linoleic acid consumption due to the increase of vegetables, grains and seeds available in the fall. Sending signals to our bodies to increase our fat stores to survive the coming winter. This is all good then, but these days, we are over consuming PUFAs at an alarming rate.

Now, you may be thinking, ok, I’ll just cut out vegetable oils and limit the processed foods I buy, great, do that! However, what about meat? Rich in healthy saturated type fats such as stearic acid from CLAs that support the health of our circulatory system, natural metabolic processes and finally lowering our low density lipids (LDSs). Well, the meats we’ve been enjoying since the 1950’s have seen an alarming increase in linoleic acid from PUFAs.

Ruminant animals have 5 stomachs to ferment low nutrient dense vegetation to refine it into a high quality proteins. Humans and other farm raised are single digestive organisms, we are able to digest nutrient dense foods. When supplemented with corn/soy led diets, health complications arise.


Well, sadly our animals are part of agrosystems that diverts animals away from their natural diets by supplementing them with high protein corn and soy feeds. Yep, even our meat is dense with PUFAs. Even those of you with “healthy diets” are probably subjected to high amounts of linoleic acid without even knowing about it.

The solution here is:

  1. Buy “Grass Finished” ruminant meats (cattle, lamb etc…) 
  2. Buy Pork that is pasteurized (they get to roam, forage and aren’t supplemented with corn/soy) or limit all together.
  3. Buy chicken that also gets to roam and live along their natural behaviors. Chicken, even at its highest quality farming, will be fed grains such as corn to some degree. Otherwise it is just too expensive to sell at market, eggs are more nutrient dense anyways!
  4. Eat organs and make bone broths! They are so nutrient dense we can’t afford not to include them in our meals like our grandparents did. They’re very affordable too by the way!


Want to learn more about the benefits of organs and bone broths? Click Here

Organs and bones are true superfoods that we owe our success as a species to. Forget kale, spinach and other vegetables that are rich in toxic acids which is an integral part of their evolutionary defensive strategy. They are saturated with toxic oxalic and phytic acids that coat our large intestines, preventing the uptake of the minerals we’re after in those vegetables anyways!

Don’t get us wrong, we love spinach but here’s the life hack, you have to cook these leafy greens or else you become riddled with a bunch of toxic compounds in your blood and stored in your fat cells. It’s not what you want. Understanding the importance of diet and the biochemistry of our bodies allows us to fully grasp the our ability to use CBD for diabetes in therapy.

The Current Research around Plant Derived PUFAs and Diabetes

We’re going to fully contradict everything stated above because diseases like diabetes and our diet isn’t a straight road unfortunately because the research is limited in certain degrees. 

Recent studies that compare much of the current primary research currently stand at it’s the type and quality of fats that impacts our diet. So yes, if you’re consuming high quality animals products as mentioned above and you exercise regularly, you’re doing well. However, if you’re already overweight, have high cholesterol and aren’t living your most health conscious lifestyle. then a high saturated fat diet may not be your best strategy here.

Poly-unsaturated fatty acids (PUFAs) may offer you a solution for weight loss, decrease of insulin resistance and glycemic regulation. Many of the recent studies in both animals and humans show that PUFAs can be a crucial part of weight loss but again, quality of the oil comes into play here (Tsalamandris et al., 2019).

But the message remains clear, this benefits some people and the other half, it doesn’t. Most of these studies recommend extra virgin olive oil and marine (fish) oils when carbohydrates aren’t  the main focus of your diet.

This means, if you’re eating a higher fat diet and reducing your carbohydrate intake then oils high in PUFAs can help you lose weight, control your cholesterol and improve your glycemic regulation. Just remember this, this is dependent on you, your lifestyle and eating habits.

Dietary recommendations that can be generalized for everyone:

  1. Cut out/reduce highly processed foods out of your diet (sodas, frozen foods, chips etc…)
  2. Eat whole meals of high quality proteins and vegetables
  3. Include some degree of movement in your daily routine, even if it’s just a 15-30 minute walk after you eat (this will add up over the day and you’ll notice your energy increase!)

Insulin Resistance & Sensitivity 

What we want to understand about insulin is that it’s a fundamental component and interacts with every type of cell in our body. Without it, our pancreas doesn’t receive proper signals to inject insulin into our system and allows for an increase of glucose in the blood to continue and an overflow of lipid cell production by our livers (Telle-Hansen et al., 2019).

This is an inflammatory response, without this fundamental lipid metabolite (insulin) our system sends signals to over produce fat cells to store all of the glucose flowing through our blood (the liver does not want to miss out on storing energy, if it doesn’t receive a signal to refrain from doing so) (Campbell et al., 2002).

What is Insulin Resistance?

Under oxidative stress the body increases its insulin resistance. Meaning, even though your cells are receiving insulin to utilize excess glucose in your blood, they are resistant to do so. So the pancreas increases the injection of insulin to cope with this (Guadarrama-Lopez et al., 2014). This is most common for Type 2 diabetes. If you have Type 1 diabetes, your body doesn’t produce enough insulin which you have to manually regulate.

What about Insulin Sensitivity?

Studies have shown you can increase your sensitivity to insulin by several means. Largely they stem from diet, lifestyle and physical activity. All of which can largely reduce the amount of oxidative stress your system endures and ultimately help keep your system in its most optimal state. Vitamine A, E and glutathione increase insulin but alpha-lipoic acid is an insulin sensitivity inducer antioxidant which is highly effective to increase sensitivity for Type 2 diabetics (Balbi et al., 2018). 

Liver, kidneys and yeast are high in alpha-lipoic acid (a potent antioxidant) (Tsalamandris et al., 2019). 

See a connection here? It’s not to be said that you cannot obtain these nutrients from vegetables, but they are more bioavailable from meats – (especially organs).

CBD for diabetes, a reduction of inflammatory response

Now we’re going to bring this all together. Let’s break this down.

  1. Diabetes is an inflammatory disease connected to lipid metabolism – Check
  2. Oxidative stress increases insulin resistance by our cells – Got it
  3. Increasing our sensitivity to insulin can be achieved by including antioxidant micronutrients such as Vitamin A and Alpha-Lipoic Acid into our diet – Sounds good
  4. We can best mitigate the harmful effects of living with diabetes by changing our diet, lifestyle behaviours and increasing physical activity – Simple enough

Inflammatory cytokines are just one example of neurotransmitters that play an important role in inflammation response systems. Diabetes is a disease that has strong cardiovascular risks associated. Taking control of your diet and lifestyles will directly affect the production of inflammatory cytokines in your body.

If we know diabetes is an inflammatory disease, we need to address the cause of our systems’ stress and inflammation and how CBD can offer therapeutic benefits for diseases such as diabetes . We now know that diet plays a huge role and PUFAs increase oxidative stress and inflammation. We haven’t addressed your lifestyle habits (ie. smoking etc…) and their effects but can say with confidence if you include physical activity into your lifestyle, you can still live a full life!

CBD specifically has strong therapeutic properties when it comes to inflammatory cytokines and pain in regards to CBD and other auto-immune diseases. 

Since your liver, pancreas, muscles, cells and so on all have CB1 and CB2 receptors as part of your ECS receive lipid transmuted signals. It should hopefully by now, be clear how CBD can help for both type 1 and type 2 diabetes (Horvath et al., 2012). 

CBD and some associated terpenes have amazing therapeutic potential. CBD can be utilized to increase pain tolerance to increase comfort. It can even address inflammation at the cellular level to help regulate the mechanisms to bring your systems back to a normal state of order (Horvath et al., 2012).

To read more about CBD, Pain and Terpenes  – Click Here

CBD products of the right concentration and cannabinoid and terpene profile can give your system a competitive advantage! With diabetes, your liver and insulin are all dependent on fatty acid regulation, CBD helps regulate the interactions of signals between cells, organs and the biochemistry of our blood (Jadoon et al., 2016). 


Hopefully now we’ve given you enough important information to simplify how we can cope and support those we care about with diabetes with the fundamentals:

Diet – highly reduced intake of poly-unstaturated fatty acids (PUFAs)

Exercise – Increase our insulin regulation and sensitivity with resistance training (more to come on that)

Lifestyle – We shouldn’t have to outline that you shouldn’t be drinking, smoking and overeating to make sure you live a long and healthy life in this article.

CBD isn’t a cure for any disease, but a tool that can offer regulatory relief. Helping our bodies by supplementing it with the cannabinoids needed to mitigate the inflammatory responses the body signals into our systems when things aren’t operating as they should be! We don’t want to over complicate things here but as you educate yourself more on CBDs therapeutic capabilities, you will have to try it yourself to really discover its true potential.

If you want to know more about what dosage you should considerClick here

Please share your thoughts and this article with someone you think would benefit from this information. 


I wrote this article because I have a number of close friends with diabetes, some who live very healthy lives and those who don’t. But even the ones who seemingly do everything right still have had further health complications because of things unbeknownst to them about their diet.

Product Suggestions if you’re interested in trying CBD yourself or buying for a loved one!

(All of our products are derived from Legal Federal Organically Grown Hemp Farms. Processed without any pesticides, heavy metals, unsafe chemicals and are lab tested – tests available on our website here)

Terpene Enhanced CBD Oil

  1. Terpene Enhanced Tinctures – Rich in Phyto cannabinoids (CBD) and terpenes that deliver the most impactful therapeutic benefits – Try Pain or Recover as they’re both high in Myrcene which is a strongly associated terpene for inflammation regulation. As mentioned above, these tinctures are our most highly suggested for CBD being used for diabetes (always consult your medical practitioner for medical advise)




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