Summary of How CBD is Being Used Therapeutically for Depression & Anxiety in 2020
With an increase of many mentally related issues, headlines are increasingly highlight the use of CBD for psychological diseases. And for good reason too.
We need to understand what is inflammation and how CBD is being used for depression and anxiety. Inflammation is a neurological response that signals immune cells to produce certain chemical reactions to cause inflammation and when to reduce it (Chavez-Castillo et al., 2019). Very quickly due to genetic polymorphisms, chemical imbalances, life events and behavioral habits these inflammatory responses can become chronic and out of balance (Chavez-Castillo et al., 2019). Depression and anxiety are two autoimmune inflammatory diseases that can be amplified and mitigated by the regulation of neurotransmitters and the inhibition of their connection to certain neurological receptors (Farooq et al., 2017).
“Treatment is available and nearly 40% of people that suffer from anxiety don’t seek treatment.” – Anxiety and Depression Association of America
It’s important to note that cannabinoids such as CBD are being researched for their application of therapeutic benefits in regards to psychological disease but there are two sides to this coin. The yes, and no. Yes, CBD and THC respectively, have the ability to act as anti-inflammatory neurotransmitters if our system is overloaded with chronic inflammation. However, in some cases, THC can signal inflammatory responses as well causing the opposite effect.
There is strong evidence that CBD can help regulate the neurological signals our brains send to our immune cells to prevent them from erratically behaving a certain way that may cause more cell damage. CBD products extracted from strong genetic plant species will have higher concentrations of CBD and associated metabolites ie. terpenes. Which in conjunction, provides for a more wholesome approach to regulating our bodies while reaping the benefits of supplementing our endocannabinoid system.
People are discovering CBD can play a pivotal role in their daily lives. Their experiences with CBD range from mental clarity all the way to pain management. Whatever you discover on your own path, you may be surprised how versatile these cannabinoids can be to our health. If you or someone you know suffers from chronic illness such as anxiety and depression, they very well may benefit from experimenting with CBD products.
Many studies show promise for CBD being used to regulate individuals symptoms of depression and anxiety by inhibiting certain neurological responses in the brain. If you want the scientific details, read beyond this summary. But if you want the quick snippet, then know this. There is a lot of research being conducted and there are many developments every year. CBD does show an ability to help people suffering from autoimmune inflammatory diseases such as depression and anxiety.
Some individuals have reported beneficial experiences to their mental health while using CBD in certain dosages with consistent daily usage. 10 mg – 30 mg daily dosages have been reported by users to enhance their sleep quality, physical and mental distress caused by their psychiatric conditions. The way we’re using CBD to treat psychological diseases in 2020 are primarily directed towards lessening the intensity and frequency of depressive and distressing episodes.
Refer to the LAST PARAGRAPH of this article for more info on full and broad spectrum CBD product suggestions.
(It is important that you never use CBD as medication to replace your current medical practitioners advice)
Anxiety Related Disorders Affect More Than 18% of U.S. Citizens
“Psychiatric disorders are affecting 10’s of millions of Americans every year according to the ADAA”
There is increasing evidence that inflammatory cytokine’s are contributing to the development of mental illness in North Americans (Felger & Lotrich, 2013). These cytokines are typically growth signals secreted out of cells during certain events such as inflammation and the process of Cytokinesis is the separation of two cells during mitosis (cell separation) into two new daughter cells (Felger & Lotrich, 2013). Cytokines play a crucial role of developing healthy brain function, having the ability to influence neurological circuitry and neurotransmitter systems which can impact behavioral patterns in the brain (Farooq et al., 2017). Inflammatory cytokines (ICs) are administered by secreting out of immune cells upon stimulation (Nagarkatti et al., 2009). That influences neurological responses for the body to mitigate infection and enhance recovery (Felger & Lotrich, 2013).
Doesn’t sound too bad eh?
Well, here’s the issue.
Chronic exposure to elevated ICs result in persistent alterations of the neurotransmitter system, leading to neuropsychiatric disorders such as depression & anxiety (Felger & Lotrich, 2013). Activating these inflammatory response signals in the brain change levels of monoamine, glutamate and neuropeptide systems, which play a pivotal role in our brains functionality (Chavez-Castillo et al., 2019). Additionally, ICs may function as mediators of environmental (trauma, obesity, stress and poor sleep) and genetic (functional gene polymorphisms) factors that contribute to the development of depression (Felger & Lotrich, 2013).
Studies are finding supportive evidence that Cannabidiol has therapeutic benefits in treating psychological disorders
Research is showing that cannabinoids such as CBD are potent anti-inflammatory agents which exert the ability to suppress Inflammatory Cytokine products and the induction of T-regulatory cells (T-regs) (Nagarkatti et al., 2009). These effects are referred to as immuno-suppressive properties.
Through our central nervous system cannabinoids compete for the same receptors (CB1 receptors) as glutamate neurotransmitters and inhibit glutamatergic synaptic transmission (Robbe et al., 2002).
English Please – the cannabinoids within our system can play a role in regulating the accumulation of inflammatory responses that affect the brain motor functions in the cerebellum by interacting with these CB1 receptors (Robbe et al., 2002).
The takeaway message here is that cannabinoids such as CBD, being an internal part of our bodies already, have the potential to regulate neurological disorders by supplementing our naturally occurring endocannabinoids.
Remember this, CBD already exists in our bodies, it’s how it has any affect at all. The fact here is the supplementary CBD we intake is interacting with our Endocannabinoids System that’s been a part of animal biology our whole evolutionary timeline.
We can use these tools to help keep our internal systems in a state of homeostasis (constant regulated state) to optimize our health and daily activity. This isn’t to say they can replace medication, however, many anti-psychotic drugs have a variety of negative side effects that may prevent an optimal treatment for the individual (Chavez-Castillo et al., 2019).
Inconclusive, the Yes but No Issue
It goes without saying there is potential here for us to help regulate our neurological pathways in order to cope more effectively with mental health. However, these studies show that there is not enough evidence that say cannabinoids such as THC (tetrahydrocannabinol) are solely anti-inflammatory. In some cases, they can act as proinflammatories for certain cytokine transmitter classes.
So where does that leave us?
With more research really.
Other than anecdotal evidence there still isn’t enough concrete information to shed a light on cannabinoids to be a solution. Those pro-inflammatory cannabinoids such as THC don’t have to be the only player in the park. CBD works in conjunction with terpenes which are natural compounds in the hemp plant that can illicit beneficial results as well without the “high” of THC.
We know that CBD and other cannabinoids can reduce the inflammatory damages caused by tissue injury. This can be invaluable for people with:
- Systemic Lupus Erythematosus
- Rheumatoid Arthritis
Which are all inflammatory diseases, but depression and anxiety are also autoimmune inflammatory diseases that can benefit from suppressive inflammatory signals (Nagarkatti et al., 2009). Cannabinoids can protect from apoptosis (cell death) in cells of the Central Nervous System (CNS), which play a protective role in autoimmune conditions such as depression and anxiety (Nagarkatti et al., 2009).
So there is evidence that cannabinoids such as CBD have some correlation to protect our cells from acting erratically by regulating the response signals our bodies send in times of physical and neurological stress.
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What each terpene is good for:
Myrcene – A terpene largely associated for it’s pain relief effects on TRVP-1 neurological receptors
B-Caryophyllene – This associated terpene has strong effects on inhibiting Chronic Inflammation Signaling
Linalool – Some studies have shown a strong correlation between the presence of linalool terpenes effects on mitigating the frequency of anxiety and depression
Humulene – Strong correlations to anti-inflammatory response signalling